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Depology's Argireline Serum and Micro Dart Patches | Weirdskin

Updated: Oct 23, 2023

A picture of the Peptide 10% Complex serum and Deepcare + Serum-Infused Micro Dart Patches from Depology skincare brand.

Having dry skin implies constantly struggling with texture, flakiness, fine lines, wrinkles, and transepidermal water loss. This is why I am a huge fan of Korean skincare products because they tend to focus on skin hydration, barrier repair, and signs of aging.

I recently discovered an innovative South Korean skincare brand called Depology which develops really advanced formulations to target these concerns and naturally couldn't pass up the chance to try two of their star products the Depology Peptide Complex 10% Serum formulated with ArgirelineTM peptide and the Depology Deepcare+ Serum-Infused Micro Dart Patches

Note that while these products were gifted to me by the brand, this review reflects my true opinion based on my experience using them.

What is the Depology Peptide Complex 10% Serum?

The Depology Peptide Complex Anti-wrinkle or the Depology Argireline serum is a product designed to prevent and reduce signs of aging such as wrinkles and fine lines on the skin. Unlike other anti-aging serums, this innovative formula prevents muscular movements in the face that cause the formation of wrinkles on the skin. To be honest, I had never heard of a skincare product being able to do that which got me really intrigued. This serum‘s star ingredient is Argireline™, an amino acid that has the ability to relax facial muscles and thus prevent wrinkle creasings from forming on the skin. Added to this, this serum also contains hydrating and antioxidant properties for plump and radiant skin.

Depology Peptide Complex 10% Anti Wrinkle Serum On a table
Depology Peptide Complex 10% Anti Wrinkle Serum

Depology Peptide Complex 10%: Ingredient List Explained

Below is a breakdown of the main active ingredients found in this serum and how they benefit the skin.

Argireline™ 10%

Argireline™ also known as peptide acetyl hexapeptide-3 is a synthetic peptide, that has various anti-wrinkle and anti-aging properties. Unlike other peptides, Argireline™ has the ability to disrupt muscle communication, this prevents the movements of muscles in the skin responsible for dynamic or expression wrinkles i.e. forehead creasing, cross feet, or fine lines around the mouth. This peptide is known to deliver anti-aging results close to that of Botulinum Toxin, promotes collagen production for smooth skin, and improves moisture in the skin.


This is an advanced form of Vitamin C made from the combination of ascorbic acid (vitamin C) and a polypeptide. This blend provides antioxidant benefits to the skin by reducing free radical damage. It also provides anti-aging benefits as Vitamin C is known to boost collagen production in the skin.

Fig Fruit Extract

This fruit extract is used in skincare for its ability to enhance the skin’s hydration levels. It also has antioxidant properties that help protect the skin from external aggressions and remastered aging.

Roman Chamomille Oil

This plant is known for its anti-inflammatory and anti-aging properties. It helps soothe irritated skin and has a significant content of antioxidant compounds that prevent free radical damage to the skin, and speed skin cell renewal which slows down signs of aging.

Vitamin E

Vitamin is a potent antioxidant that targets signs of premature aging. In addition to this, it helps with skin hydration and also has anti-inflammatory benefits for the skin.

Centella Asiatica

Also known as cica, this plant active is very popular in K-beauty products. Centella asiatica is one of the most versatile actives used in cosmetics and its benefits range from soothing, and hydrating to strong antioxidants capable of preventing skin aging caused by free radicals and UV exposure.

Heartleaf Extract

Heart leaf extract has been used for centuries in both Korean and Chinese traditional medicine before becoming popular in skincare. This active is known to be a potent antioxidant that protects the skin from aggressions and fights signs of skin aging. It also has anti-inflammatory and antibacterial properties that contribute to maintaining skin health.

My Experience with the Depology Argireline™ Peptide Serum

Habiba's skin before using Depology Peptide Complex 10% Argiline
Before the Peptide Complex 10% Argireline™ peptide Serum

I received the Argireline™ peptide serum at a point where my skin barrier was impaired which was kind of ideal for me. Peptides are great for skin barrier repair as they rebuild the skin’s lipid layers. Prior to use my skin was very dry, bumpy, dull, and felt very irritated. I used this serum twice a day alongside a gentle cleanser and a soothing moisturizer.

The serum was very light on my skin and absorbed very fast without irritating my already sensitive skin. 3 drops were enough to cover my face and the first thing I noticed was how hydrating this serum is.

Habiba's skin two weeks after using the Depology Peptide Complex 10% Argireline
2 weeks after the Peptide Complex 10% Argireline™ Peptide Serum

After 2 weeks of use my skin was significantly more plump, and my and its texture was smoother. Did my wrinkles go away? Well, 2 weeks is too short for an honest response but the improvement in my skin’s plumpiness is a sign that over time this serum will deliver even better results.

The Depology Deepcare+ Serum-Infused Micro Dart Patches

Of the two products I received, the Depology Micro Dart under eye patches is what piqued my interest the most. Imagine the combination of an eye mask and micro-needles. These eye patches unlike silicon and hydrogel eye patches are not covered in serum. The part that comes in contact with the under eye area has tiny micro darts that just like micro needles cause micro injuries to the skin. This, in turn, triggers the skin’s healing process while infusing the skin with anti-aging actives like hyaluronic acid, Argireline, various amino acids, and trehalose. The result guaranteed is more hydrated, glowing, and plumper skin.

In addition to this delivery through micro darts has other benefits on the skin such as improving skin texture, and scars, brightening, and evening the skin tone.

Star Ingredients in the Depology Deepcare+ Serum-Infused Micro Dart Patches

Hyaluronic Acid

Hyaluronic acid is a strong humectant that draws moisture in the skin and binds water to collagen for more plump, and hydrated skin. This action helps prevent and get rid of wrinkles and fine lines. This humectant is infused into the skin via microneedles and helps boost collagen in the skin.

Amino Acids

Amino acids make the building block of the skin’s matrix and are necessary for various skin functions such as collagen production, and water retention.


The Depology micro-needling eye patches contain a blend of peptides (Argireline™, Lysine Polypeptide, Tripeptide-1, Palmitoyl Pentapeptide-4) that boost collagen production, increase skin water retention, and result in firmer and more plump skin. This is ideal for people with crow's feet around the eyes, dark circles, and expression wrinkles.


Adenosine is an anti-wrinkle agent that has the ability to boost collagen production by stimulating the formation of fibroblasts (cells that secrete collagen in the skin) which helps improve the appearance of wrinkles.


Trehalose is a sugar that has both moisturizing and antioxidant properties. It is used in skincare for its capacity to reduce stress on skin caused by UV exposure and free radicals which are the principal cause of skin aging.

My Experience with the Depology Deepcare+ Serum Micro Dart Patches

Using these eye patches felt like receiving a home microneedling session and at first was jarring but I loved it I was gifted with two packs of 4 pairs each (i.e. 16 patches) and at the time of this review I have used 4 pairs.

Picture of Habiba before using Depology's Deepcare + Serum Micro dart Patches
Before the Depology Deepcare + Serum Micro dart Patches

The directions require applying the patches on clean and dry skin for a minimum of 2 hours or overnight for best results every 2-3 days. I wore them for both 2hrs and overnight and was so surprised at how the glue on this stuff holds. it literally griped to my skin and stayed on for a full night which is very impressive.

After wearing the patches I lightly pressed the area with the micro darts into my skin which was not painful at all. After taking them off, my under-eye area did feel more hydrated than the rest of my skin and slightly more plump. Honestly, this was faster than most eye creams I have used in the best and a million times less messy than regular hydrogen eye masks. See pictures.

Picture of Habiba after using Depology's Deepcare + Serum Micro dart Patches
After using the Depology Deepcare + Serum Micro dart Patches

Although the pictures attached above of the results do not show a drastic change, I promise you it did improve the firmness of my under eye area which appeared plumper (you see my under eyes are less sunken in the second picture) and I am sure but the time I’ll be done with the 8 pairs my under eye area will definitely look better (so stick around for an update in a few weeks).

Final Thoughts

Honestly discovering the Depology brand was such a positive experience and their formulations are quite different from what I am used to. The Depology Peptide Complex 10% Serum with Argireline™ was really impressive with the way it plumped up my skin and helped improve my skin texture.

It’s one of the most promising anti-aging products I have tried so far in my skincare journey and this will pair really well with retinol. I see myself using this more often for skin prep before makeup since I have smile lines that cause my foundation to crease a lot. this serum will definitely stay in my routine for a while.

Using the Depology Deep+Care Serum Micro Dart Patches really felt like a spa session at home. The technology behind these eye patches really stood out for me and the delivery was unlike anything I have ever seen before. My under-eye area felt more hydrated and plump after using 4 pairs of Micro Dart which is the fastest result I have ever gotten from an under-eye serum I can wait for patches and I really like the fact they aren’t messy to use and stick for a really long time.

If you are struggling with dry skin like me, dehydrated, or have mature skin and are trying to get rid of fine lines and wrinkles then you should really give Depology products a try. I definitely recommend the Peptide Complex 10% Argireline™ peptide Serum to get plump and radiant skin and the Deepcare+ Serum Micro dart Patches are ideal to get rid of crow feet.


How Long Do Peptides Take To Work?

The effects of peptides on the skin, such as improved texture or reduced fine lines, typically become noticeable after 4 to 12 weeks of consistent use, though results can vary based on the specific peptide product, its concentration, and individual skin factors.

How To Use Depology Peptide Complex Serum?

  1. Cleanse: Thoroughly wash your face to remove dirt and makeup.

  2. Tone: If you use a toner, apply it after cleansing.

  3. Depology Peptide Complex Serum: Apply a small amount to your face and neck, massaging gently in upward and outward motions until fully absorbed. Allow a few minutes for the serum to penetrate your skin.

  4. Moisturize: Follow up with your preferred moisturizer to lock in the serum's benefits.

  5. Sun Protection: If it's daytime or you'll be exposed to sunlight, finish with sunscreen to protect your skin.

Always conduct a patch test when introducing a new skincare product to your routine to check for sensitivities.

Is Depology A Korean Brand?

Yes, Depology is a Korean skincare brand dedicated to consistently innovating and exploring fresh avenues in the ever-changing landscape of beauty and skincare. The brand's aspiration is to empower individuals to embrace their skin confidently through potent, yet gentle skincare solutions

Do Micro Dart Patches Work?

The Depology Micro Dart Patches help prevent and treat signs of aging as well as hydrate and re-plump the skin. For significant results use patches at least twice a week and wear them overnight.

Where Do I Buy Depology Products?

You can purchase Depology products on their official website here.


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